141 Portland Street is a state-of-the-art life science building proposed for Boston’s Bulfinch Triangle subdistrict. With a deep appreciation for the historic fabric that surrounds it, the building’s façade design incorporates analysis of architectural elements, materiality, and proportion that characterize the neighborhood. Beyond the exterior, the building’s layout promotes interaction and knowledge sharing among its occupants, fostering a vibrant community of innovators and researchers. By connoting innovation and celebrating the rich heritage of the Bulfinch Triangle, 141 Portland promises to become a vital contributor to Boston’s scientific and architectural legacy.